Functional status of mast cells with experimental hypoheparinemia

We have studied the characteristics of the functional state of mast cells in animals with experimental hyperlipidemia under hypoheparinemia. Stated that the chronic introduction of the blocker heparin animals showed an increase in activity of mast cells accompanied by increased total degranulation of cells. This, in our opinion, cause disorder of the lipid transport system as a whole, with the formation of structural and functional abnormalities in the vessel wall atherogenic direction. The animals that were only on atherogenic diet, observed a sharp increase in the number of mast cells and their secretory activity on the background reduction in the number of mature cells, which may indicate a compensatory mechanism by the lipid-transport system at the cellular level. Keyword: mast cells, heparin, atherogenic diet.